Aura+ is the latest instrument designed specifically to detect, count, and characterize subvisible aggregates and extrinsic materials for product quality measurements in both AAV and lentiviral gene therapy applications. Aura+ outputs images, count, size, particle identification and morphological information with 100% sampling efficiency requiring as little as five microliters of sample volume through Backgrounded Membrane Imaging and Fluorescence Membrane Microscopy (FMM). FMM identifies aggregates as cellular, protein, or extrinsic so you can quickly know what is in your sample. Specifically, Aura+ has the capability to detect SYBR® Gold stain, which is used to detect the presence of DNA in AAV or lentiviral aggregation to understand the role of leaky capsids in subvisible particle formation often leading to reduced AAV transduction efficiency and adverse patient responses. Aura+ can also use protein- or lipid-specific fluorescent stains to provide further insight into particle characterization.

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