Cell Characterization & Antibody Cell Line Development

Our cutting-edge technology offers comprehensive insight into the composition of your cell therapies, enabling you to distinguish cellular from noncellular aggregates for precise purity analysis.

Do You Know What's Really in Your Sample?


Why Use Aura to Identify Cellular and Non-Cellular Particles?

  • Definitively ID subvisible particles using fluorescent cell and other particle specific stains
  • Obtain detailed information on particles that other methods can’t deliver, including size, morphology, count, and distribution
  • Small to large cellular aggregate characterization in highly heterogeneous solutions
  • 100x higher throughput compared to standard flow imaging and cytometry techniques for testing lots of formulations, conditions, and lot releases
  • Fluidics-free rapid analysis time
  • Evaluate a wide range of particle sizes, measuring 1 μm to 5 mm with high reproducibility
  • Maintain compliance with the option for 21 CFR Part 11 software

Accurately Distinguish Between Cellular and Non-Cellular Particles

Make Better Decisions About Your Therapeutics

Accurately Monitor Cell Behavior

With Aura CL, you can easily determine if your therapeutic formulation or storage is the cause of cell aggregation.

Utilizing either DAPI or Hoechst staining to label nuclei and performing a comparison with BMI imaging gives an in-depth overview on whether singlets, doublets, triplets and beyond are present within your cellular population.

Particle Vue Software

Get particle analysis answers in just a few clicks with flexible, easy-to-use Particle Vue Software.

Frequently Asked Questions

All cells share certain fundamental characteristics, some of these including:

  • Plasma Membrane: Cells are surrounded by a plasma membrane that separates the cell from its environment and regulates the passage of molecules in and out of the cell.
  • Genetic Material: Cells contain genetic material, typically DNA (deoxyribonucleic acid) in the form of chromosomes, which carries the instructions for cell function and heredity.
  • Cytoplasm: The cytoplasm is the gel-like substance inside the cell that contains various organelles, such as mitochondria, endoplasmic reticulum, and ribosomes, involved in cellular processes.
  • Metabolism: Cells carry out metabolic processes to obtain energy and synthesize biomolecules necessary for cell growth, maintenance, and function.
  • Reproduction: Cells have the ability to reproduce and divide to produce new cells through processes such as mitosis or meiosis.

These fundamental characteristics are essential for the survival and function of all cells, regardless of their type or function within an organism.

Cell characterization  assesses various properties and attributes of cells to understand their identity, behavior, and function. Common techniques used for cell characterization include:

  • Morphological Analysis: Observing cell shape, size, and structure using microscopy or imaging techniques.
  • Cell Proliferation and Viability Assays: Assessing cell growth, proliferation, and viability using techniques such as cell counting, metabolic assays, or flow cytometry.
  • Cell Surface Marker Analysis: Identifying specific cell surface markers or antigens using techniques such as flow cytometry or immunofluorescence staining.
  • Genetic Analysis: Analyzing gene expression profiles, mutations, or genetic modifications using techniques such as PCR (polymerase chain reaction) or gene sequencing.
  • Functional Assays: Evaluating cellular functions such as migration, differentiation, or cytokine secretion using specialized functional assays.

Cell characterization provides valuable insights into cell identity, behavior, and function, aiding in research, drug development, and clinical applications.

Cell line testing involves assessing the characteristics, purity, and stability of cell lines used in research, drug development, or manufacturing processes. This includes verifying the identity of the cell line, ensuring absence of contamination, and monitoring genetic stability over time. Cell line testing is essential to maintain reproducibility, reliability, and safety in experimental and therapeutic applications involving cell lines.