Particle ID
5 µL - 10 mL Sample Volume
1 Minute/Sample
100% Sampling
About Aura
High-Throughput Particle Counting, Sizing, and Identification
The Aura™ system is the particle analysis platform that gets you to your best formulation faster. It combines Fluorescence Membrane Microscopy (FMM) technology with Backgrounded Imaging (BMI) technology to give you a low volume, high-throughput system that counts, sizes, and IDs protein aggregates. Translation? You can now screen particles as early as lead optimization and pre-formulation testing to gain key drug stability insights earlier, reducing development risk and time to market.
Get the Aura instrument that fits best with your workflow – a brightfield only system that can be updated later, a 1-channel fluorescence system that gives you brightfield and detects ThT labeled protein aggregates, or a 2-channel fluorescence system that adds an additional fluorescence channel to your system. And did we mention that the Aura counts and measures 100% of your sample so sample focus and flow rates won’t ever bias your data? Never worry about what you’re missing with the Aura!
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Why Aura?
Know What’s Protein and What’s Not
Definitively determine if your particles are protein or not in your stability analysis and contaminant detection by using Thioflavin T, a fluorescent dye that specifically binds to protein aggregates.
Fluorescence Labeling of Your Choice
Get the flexibility needed to identify other particles in your formulation. Choose between channels for TMA, Bodipy, DiI, to identify hydrophobic entities or other molecules specific to your process. Don’t see the channel you want? Select your own custom excitation and emission!
Minimal Optimization
Only the Aura system measures 100% of your sample and keeps all of the particles in the same plane of focus. Get accurate counts right away, without having to optimize the frame rate and flow rate.
Full Automation
Looking for ways to increase your efficiency? Not only is the 96-well membrane plate compatible with liquid handlers, but the Aura system is fully robotic-compatible as well.
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The ring light works as a status bar, keeping you posted on your experiment’s progress, even across the room.
Large Size Range
1 µm – 5 mm. See the smallest subvisible to the largest visible particles, all in one tool.
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Which Aura Is Right for You?
| Application | Aura BMI | Aura FL1 | Aura FL2 | Aura CL | Aura GT |
|---|---|---|---|---|---|
| Particle Detection/Quantitation | |||||
| Extrinsic Particles | |||||
| Protein ID | |||||
| Polysorbate ID | |||||
| Cell Aggregate ID | |||||
| Capsid Aggregate ID | |||||
| DNA Leakage | |||||
| Immunoassays | |||||
| Cellular Assays | |||||
| Custom FL Applications |
| Therapeutic Area | Aura BMI | Aura FL1 | Aura FL2 | Aura CL | Aura GT |
|---|---|---|---|---|---|
| Protein/Antibody | |||||
| Small Molecule | |||||
| Gene Therapy | |||||
| Cell Therapy |
Aura in Your Lab
Protein/Non-protein ID
Distinguish between protein and non-protein particles with fluorescence detection.
Polysorbate Degradation
Know the source of particles if you formulation – distinguish aggregated drug product from degraded excipients.
High Concentration Samples
Ideal for antibody particle analysis or any limited material samples with high viscosity and high refractive index.
Analytical Development and Quality Control
Particle identification assists with forensics. 21 CFR Part 11 software available.
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