Antibody-producing Chinese hamster ovary (CHO) cell lines have been long used to produce antibodies without aggregation in mind. Aura+® is the first instrument designed to characterize antibody stability as early as cell line development (CLD). Aura+ enables low volume, high throughput subvisible particle imaging, counting, sizing, and identification. It easily handles and analyses the biologically complex cellular and protein samples present in CLD to characterize protein stability at the point of production, following release from CHO cell lines.
In this webinar, we will show how Aura+® quickly and accurately characterizes secreted antibody stability during CHO CLD in unfiltered cell line samples, and how it uses antibody labelling that requires volumes as low as 40 µL per sample. In addition, we will discuss how the Aura+ has the capability to rapidly assess different formulation strategies and, for the first time, how it can distinguish polysorbate degradants from other protein aggregates through the application of a novel fluorescent workflow.
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