Characterizing the Stability of Gene Therapy Products at Ultra Low Volume
In this GEN webinar, Dr. Bernardo Cordovez will discuss Aura® GT and how to characterize gene therapies for stability and CQAs using a minuscule amount of sample. With this novel platform, drug products and particles can be quantitated for size and count, imaged by microscopy for morphological features, and identified via labeled fluorescence by fluorescence membrane microscopy, using a fraction of the sample requirement compared to other methods. Dr. Cordovez will also discuss the technique of fluorescently labeling DNA payloads to understand its impact on subvisible aggregate formation for AAV product stability and shelf life. As a result, gene therapy developers finally have the cutting-edge tools required to develop advanced science and medicine.